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KMID : 0603820150210040165
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Journal of Experimental & Biomedical Science
2015 Volume.21 No. 4 p.165 ~ p.171
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Future Perspectives on New Approaches in Pathogen Detection
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Peng Li
Bow Ho
Jeak Ling Ding
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Abstract
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Microbial pathogens are responsible for most of the rapidly-spreading deadly infectious diseases against humans. Thus, there is an urgent need for efficient and rapid detection methods for infectious microorganisms. The detection methods should not only be targeted and specific, but they have to be encompassing of potential changes of the pathogen as it evolves and mutates quickly during an epidemic or pandemic. The existing diagnostics such as the antibody-based ELISA immunoassay and PCR methods are too selective and narrowly focused; they are insufficient to capture newly evolved mutant strains of the pathogen. Here, we introduce a fresh perspective on some new technologies, including aptamers and next generation sequencing for pathogen detection. These technologies are not in their infancy; they are reasonably mature and ready, and they hold great promise for unparalleled applications in pathogen detection.
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KEYWORD
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Pathogen detection, Pathogen mutation, Antibiotic resistance, Aptamers, Next generation sequencing
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